Peptide Database

Peptide NameCycloviolacin VY1

Function Ontology

—

Standard StatusStandard

Sequence Length28 amino acids

Chemical FormulaC123H202N34O39S6

DescriptionStandard

        CGESCVFIPCISSVIGCSCKSKVCYRNS
    

Molecular Weight2973.51 Da

Isoelectric Point (pI)8.33

Net Charge (pH 7.0)1.70

Net Charge (pH 7.4) 1.40

Charge Density (pH 7.0) 0.0607

GRAVY Index0.57

Hydrophobic Moment 0.37

Boman Index0.13

Instability Index32.91

Aliphatic Index 72.86

Aromaticity 0.0714

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1176.17

LogP -15.65

H-bond Donors 48.0

H-bond Acceptors 47.0

Rotatable Bonds 96.0

Heavy Atoms 202.0

Ring Count 3.0

Amide Bonds 28.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0093794 VERIFIED: YES

Provenance & Taxonomy

OrganismViola baoshanensis [Plant]

FamilyCyclotide

Structure & Mods

Configcyclic cystine-knot cyclotide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideThree-disulfide cyclic cystine knot

Other ModsHead-to-tail backbone cyclization

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli TOP10 peptide-expressing strain

Activity4.19 OD_ID (dimensionless)

MethodMeX pooled intracellular peptide-expression growth-inhibition assay (NGS-derived OD_ID at 4.5 h)