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MYP_137448
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Basic Information
Human drosomycin-like defensin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
43 amino acids
C186H310N74O59S7
Standard
Sequence
CLAGRLDKQCTCRRSQPSRRSGHEVGRPSPHCGPSRQCGCHMD
Physicochemical Analysis
4751.37 Da
9.25
4.97
4.52
0.1156
-1.13
0.66
-0.40
125.06
27.21
0.0000
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2158.27
-33.14
83.0
74.0
155.0
326.0
7.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0030307 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Defensin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
Fusarium oxysporum
6.25 μM
MIC
PaperDrosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity
RECORD: Rec_0042932 VERIFIED: YES
Provenance & Taxonomy
Drosophila melanogaster [Animal]
Defensin
7227
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antifungal
F. solani
25 μM
MIC
PaperDrosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity
RECORD: Rec_0054692 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli
50 μM
MIC
PMID18212107 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18212107/
RECORD: Rec_0059544 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 9.3%, E 16.3%, T 37.2%, C 37.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0088423 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Defensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antifungal
oxysporum
6.25 μM
MIC
PMID18212107 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18212107/
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