Peptide Database

Peptide NameHuman drosomycin-like defensin

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length43 amino acids

Chemical FormulaC186H310N74O59S7

DescriptionStandard

        CLAGRLDKQCTCRRSQPSRRSGHEVGRPSPHCGPSRQCGCHMD
    

Molecular Weight4751.37 Da

Isoelectric Point (pI)9.25

Net Charge (pH 7.0)4.97

Net Charge (pH 7.4) 4.52

Charge Density (pH 7.0) 0.1156

GRAVY Index-1.13

Hydrophobic Moment 0.66

Boman Index-0.40

Instability Index125.06

Aliphatic Index 27.21

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2158.27

LogP -33.14

H-bond Donors 83.0

H-bond Acceptors 74.0

Rotatable Bonds 155.0

Heavy Atoms 326.0

Ring Count 7.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011887 VERIFIED: YES

Provenance & Taxonomy

OrganismDrosophila melanogaster [Animal]

FamilyDefensin

Tax ID7227

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antifungal

TargetA. ustus

Activity12.5 μM

MethodMIC

RECORD: Rec_0015002 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetC. tropicalis

Activity50 μM

MethodMIC

RECORD: Rec_0019396 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetKlebsiella pneumoniae

Activity50 μM

MethodMIC

RECORD: Rec_0020762 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetAspergillus ustus

Activity12.5 μM

MethodMIC

RECORD: Rec_0026770 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyDefensin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetAspergillus nidulans AZN 2867

Activity6.25 μM

MethodMIC

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