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MYP_137436
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Basic Information
Kalata B2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C122H188N34O41S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCSCTWPICTRD
Physicochemical Analysis
2979.39 Da
4.67
-1.29
-1.59
-0.0446
0.11
0.27
0.16
47.28
36.90
0.0690
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1168.51
-16.68
46.0
46.0
86.0
203.0
6.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0236416 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
cyclic cystine-knot cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Three-disulfide cyclic cystine knot
Head-to-tail backbone cyclization
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0243945 VERIFIED: NO
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Defensin
Structure & Mods
cyclic cystine-knot cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Head-to-tail backbone cyclization
Bio-Activity Profile
Insecticidal
PaperPubMed PMID: 10600388 | PubMed PMID: 15654741 | PubMed PMID: 17534989 | PubMed PMID: 20564013 PMID10600388;15654741;17534989;20564013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0253815 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
cyclic cystine-knot cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Three-disulfide cyclic cystine knot
Head-to-tail backbone cyclization
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Membrane-Binding Insecticidal Hemolytic Antiviral Antiparasitic Anti-Gram-negative
Pseudomonas aeruginosa
40 μM
MIC
PaperPubMed PMID 2056401 | PubMed PMID 3156547 | PubMed PMID 4000000 | Fensterseifer IC et al., 2014 | Printing M et al., 2010 PMID20564013 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2056401/
RECORD: Rec_0265748 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Viola betonicifolia [Synthetic]
32630
Structure & Mods
cyclic cystine-knot cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Three-disulfide cyclic cystine knot
Head-to-tail backbone cyclization
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Insecticidal Antibacterial
Staphylococcus aureus
50 μM
MIC
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0290159 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Viola betonicifolia [Synthetic]
32630
Structure & Mods
cyclic cystine-knot cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Three-disulfide cyclic cystine knot
Head-to-tail backbone cyclization
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Insecticidal
Candida albicans
>160 μM
MIC
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
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