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MYP_137436
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Basic Information
Kalata B2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Binding / Molecular interaction ▸ Binding activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C122H188N34O41S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCSCTWPICTRD
Physicochemical Analysis
2979.39 Da
4.67
-1.29
-1.59
-0.0446
0.11
0.27
0.16
47.28
36.90
0.0690
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1168.51
-16.68
46.0
46.0
86.0
203.0
6.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0176383 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclic Peptide
60225
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Nematocidal Anthelmintic Molluscicidal Membrane-Binding Insecticidal Hemolytic Antiviral Antiparasitic Anti-Gram-negative
Pseudomonas aeruginosa
80 μM
MIC
PaperPubMed PMID 2056401 | PubMed PMID 3156547 | PubMed PMID 4000000 | Fensterseifer IC et al., 2014 | Printing M et al., 2010 PMID2056401;3156547;4000000;20564013;15654;74000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2056401/
RECORD: Rec_0208320 VERIFIED: YES
Provenance & Taxonomy
Oldenlandia affinis [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0209752 VERIFIED: YES
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0222631 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Viola betonicifolia [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Antiparasitic Insecticidal
Staphylococcus aureus
>160 μM
MIC
PaperPlant cyclotides: A unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif. PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0224808 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
W at position 23 is oxidated
Bio-Activity Profile
Antibacterial Antiviral Antiparasitic Toxic Antimicrobial Antifungal Anti-Gram-positive Cytotoxic Insecticidal
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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