Peptide Database

Peptide NameSLAY-screened peptide P4567

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC76H128N26O25S2

DescriptionStandard

        RLLICAPAREHGSDMSN
    

Molecular Weight1870.12 Da

Isoelectric Point (pI)6.74

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.43

Charge Density (pH 7.0) -0.0093

GRAVY Index-0.36

Hydrophobic Moment 0.37

Boman Index-0.12

Instability Index47.38

Aliphatic Index 80.59

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 830.76

LogP -10.15

H-bond Donors 30.0

H-bond Acceptors 28.0

Rotatable Bonds 61.0

Heavy Atoms 129.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006908 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/