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MYP_137407
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Basic Information
HPA3NT3-F1AF8A (HPA3NT3 peptide analogs)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C92H155N27O17
Standard
Sequence
AKRLKKLAKKIWNWK
Physicochemical Analysis
1911.39 Da
11.43
6.79
6.59
0.4527
-1.17
0.83
-0.40
15.40
91.33
0.1333
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
763.41
-2.28
28.0
24.0
69.0
136.0
4.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0146999 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
Non-hemolytic against hRBCs
Hemolysis
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0157920 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
32 μM
MIC
PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0180585 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
A. flavus
32 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0190852 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
16 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
RECORD: Rec_0220734 VERIFIED: YES
Provenance & Taxonomy
Helicobacter pylori [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
2 μM
MIC
PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/
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