Peptide Database

Peptide NameHPA3NT3-F1AF8A (HPA3NT3 peptide analogs)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC92H155N27O17

DescriptionStandard

        AKRLKKLAKKIWNWK
    

Molecular Weight1911.39 Da

Isoelectric Point (pI)11.43

Net Charge (pH 7.0)6.79

Net Charge (pH 7.4) 6.59

Charge Density (pH 7.0) 0.4527

GRAVY Index-1.17

Hydrophobic Moment 0.83

Boman Index-0.40

Instability Index15.40

Aliphatic Index 91.33

Aromaticity 0.1333

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 763.41

LogP -2.28

H-bond Donors 28.0

H-bond Acceptors 24.0

Rotatable Bonds 69.0

Heavy Atoms 136.0

Ring Count 4.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0085059 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0094464 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetS. typhimurium

Activity2 μM

MethodMIC

RECORD: Rec_0125752 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetBacillus subtilis

Activity4 μM

MethodMIC

RECORD: Rec_0145471 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetAspergillus fumigatus

Activity4 μM

MethodMIC

PaperAntimicrobial HPA3NT3 peptide analogs: placement of aromatic rings and positive charges are key determinants for cell selectivity and mechanism of action. Biochim Biophys Acta. 2013 Feb;1828(2):443-454. doi: 10.1016/j.bbamem.2012.09.005. PMID: 22982494. PMID22982494 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22982494/

RECORD: Rec_0146650 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicobacter pylori [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetA. parasiticus

Activity8 μM

MethodMIC

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