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MYP_137403
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Basic Information
BacW2R (cyclic derivative of bactenecin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
15 amino acids
C86H154N34O16S2
Standard
Sequence
RRLCRIVWVIRVCRR
Physicochemical Analysis
1984.49 Da
12.00
5.74
5.51
0.3827
0.17
0.68
-0.45
74.39
136.00
0.0667
5500.00
5625.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
857.91
-5.54
37.0
24.0
66.0
138.0
2.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049108 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-cyclized bactenecin derivative [Cyclic]
canonical L-amino-acid peptide [L]
Intramolecular disulfide bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis ATCC 29212
2 μg/mL
MIC
PaperWu M, Hancock REW. Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999;43:1274-1276. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0165043 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-cyclized bactenecin derivative [Cyclic]
canonical L-amino-acid peptide [L]
Intramolecular disulfide bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K-12
2 μg/mL
MIC
PaperWu M, Hancock REW. Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999;43:1274-1276. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0169303 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-cyclized bactenecin derivative [Cyclic]
canonical L-amino-acid peptide [L]
Intramolecular disulfide bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Gram-positive and Gram-negative bacterial test panel
broth microdilution MIC assay
PaperWu M, Hancock REW. Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999;43:1274-1276. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0267739 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-cyclized bactenecin derivative [Cyclic]
canonical L-amino-acid peptide [L]
Intramolecular disulfide bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
S. mitis
0.25 μg/mL
MIC
PaperWu M, Hancock REW. Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999;43:1274-1276. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0273099 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-cyclized bactenecin derivative [Cyclic]
canonical L-amino-acid peptide [L]
Intramolecular disulfide bond
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Corynebacterium xerosis
0.25 μg/mL
MIC
PaperWu M, Hancock REW. Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999;43:1274-1276. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
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