Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length455 amino acids

Chemical FormulaC2235H3518N556O655S22

DescriptionStandard

        MLHFVIVALMLLPHTCGQNPAIQVLLTNKGLQYGKHVGAEWIQDMLDHVTLPDIQGTFSTLFGPVSYTLSGITITKCDFPEPNVEYSQEYSGFKTSITDLSVALSGNWATKFGILHESGSFDMAIFGVDVTSVVKLEGKADGHLSVSSIICDGEVQDVDIRLYGGFSWIFQPFVHYMKGHIIEEIRKNICPAVQTSIEELESHLQAMNVSFDVNQVLSLELPLSGSPVVSPSNLTLGLKGEFYSIQTHAEPPFKSKPFMMPNIPGYMLSAGVSEFTLNSAAYGYFSAGKLQILITEKMVSAVMKNINTQAEGVFLPKLFPGLPMTLQVYATEAPTFSLQSDIVNLTVRAAVKASAVESNGSSIPLFGVNVVVMLSGKMWIADGKVKGSVMLNNFTLTLASTQVGPFKVDEKKTSGVSEKLAEGVMLPRMKRIQPVNSILTGFIAISSDAQVLDML
    

Molecular Weight49362.60 Da

Isoelectric Point (pI)5.50

Net Charge (pH 7.0)-9.62

Net Charge (pH 7.4) -10.50

Charge Density (pH 7.0) -0.0211

GRAVY Index0.23

Hydrophobic Moment 0.60

Boman Index0.21

Instability Index38.03

Aliphatic Index 98.48

Aromaticity 0.0857

Extinction Coeff. Reduced 38390.00

Extinction Coeff. Oxidized 38640.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0242494 VERIFIED: NO

Provenance & Taxonomy

OrganismOryzias sinensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence