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MYP_137362
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Basic Information
P21S8Z
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LDLTYEXLSLQXVVKXLNESY
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0274060 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
MERS-CoV | Huh-7 cells
0.63±0.05 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0277803 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
Q1020R-MERS-CoV pseudovirus | calu-3 cells
2.49±0.18 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0319765 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral Anti-MERS-CoV Fusion inhibition
WT MERS-CoV pseudovirus | calu-3 cells
2.8±0.74 μM
EC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0322165 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral Anticancer
Human hepatocellular carcinoma Huh7
50-60 %
cell-viability/cytotoxicity assay
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0393409 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Calu-3 cell
100 μM
CC50
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
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