‹ ›
MYP_137362
← PREVIOUS NEXT → BACK
Basic Information
P21S8Z
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
LDLTYEXLSLQXVVKXLNESY
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0081632 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antimicrobial Antiviral
Q1020H-MERS-CoV pseudovirus:inhibition of pseudovirus infection in calu-3 cells
4.15±0.25 μM
EC50
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0091446 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral
MERS-CoV PsV
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0097346 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antimicrobial Antiviral
WT MERS-CoV pseudovirus:inhibition of pseudovirus infection in calu-3 cells
2.8±0.74 μM
EC50
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0145343 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antiviral
Cov-Q1020H PsV
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
RECORD: Rec_0173041 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled α-helical peptide [Cyclic]
noncanonical residue-containing peptide [Modified]
Acetylation
Amidation
Hydrocarbon staple; X denotes noncanonical residues specified in source nomenclature
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperWang C et al. Discovery of hydrocarbon-stapled short alpha-helical peptides as promising MERS-CoV fusion inhibitors. J Med Chem. 2018;61:2018-2026. PMID29442512 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29442512/
1 2 3 4 NEXT LAST
Showing 5 records · Page 1 of 4