Peptide Database

Peptide NameSLAY-screened peptide P3039

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC99H152N26O28

DescriptionStandard

        TPKVQGGQDVAPPRPSPLFY
    

Molecular Weight2154.42 Da

Isoelectric Point (pI)8.25

Net Charge (pH 7.0)0.40

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0199

GRAVY Index-0.69

Hydrophobic Moment 0.23

Boman Index-0.00

Instability Index94.08

Aliphatic Index 53.50

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 844.36

LogP -8.26

H-bond Donors 26.0

H-bond Acceptors 29.0

Rotatable Bonds 60.0

Heavy Atoms 153.0

Ring Count 7.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238713 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/