Peptide Database

Peptide Namepeptide 5 (Derived from Mag2)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC94H156N24O19

DescriptionStandard

        GIKKFLKSAKKFGKAFK
    

Molecular Weight1926.39 Da

Isoelectric Point (pI)10.78

Net Charge (pH 7.0)6.75

Net Charge (pH 7.4) 6.54

Charge Density (pH 7.0) 0.3972

GRAVY Index-0.51

Hydrophobic Moment 0.84

Boman Index-0.15

Instability Index-19.41

Aliphatic Index 57.65

Aromaticity 0.1765

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 731.29

LogP -3.83

H-bond Donors 26.0

H-bond Acceptors 26.0

Rotatable Bonds 72.0

Heavy Atoms 137.0

Ring Count 3.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0079743 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 9 and 13) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetmultidrug-resistant Pseudomonas aeruginosa

Activity3.125 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0087444 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 9 and 13) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Hemolytic

Targethuman red blood cells

Activity1.56 μM

MethodHemolysis

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0240021 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 9 and 13) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetEscherichia coli

Activity1.56 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0273592 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 9 and 13) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity12.5 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/

RECORD: Rec_0278194 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyMagainin

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermAmidation

Other ModsThe Ⓧ (position: 9 and 13) in sequence indicate (S)-4-pentenyl alanine. Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling through an oct-4-enyl hydrocarbon staple

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa

Activity6.25 μM

MethodMIC

PaperMotoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu. Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence. Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444. PMID33466998 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33466998/