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MYP_137230
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Basic Information
Unnamed
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
13 amino acids
C78H134N20O17
Standard
Sequence
LLRHVVKILEKYL
Physicochemical Analysis
1624.02 Da
9.70
1.85
1.59
0.1421
0.60
0.82
0.11
44.93
194.62
0.0769
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
612.67
0.06
22.0
20.0
56.0
115.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0413743 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]; synthetic construct [Synthetic]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
HepG-2
50 μg/mL
inhibition assay
PaperWang C et al. Designed synthetic analogs of the alpha-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin alpha-v beta-3 homing domain. J Pept Sci. 2012. PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0418534 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]; synthetic construct [Synthetic]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Hep-G2 (50.90 Inhibition ratio at 50 μg/ml)
MTT/MTS cell-proliferation and cytotoxicity assay
PaperWang C et al. Designed synthetic analogs of the alpha-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin alpha-v beta-3 homing domain. J Pept Sci. 2012. PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
RECORD: Rec_0425036 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]; synthetic construct [Synthetic]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10 peptide-expressing strain
3.83 OD_ID (dimensionless)
MeX pooled intracellular peptide-expression growth-inhibition assay (NGS-derived OD_ID at 4.5 h)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (MeX). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7. PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0427193 VERIFIED: YES
Provenance & Taxonomy
Lithobates catesbeianus [Animal]; synthetic construct [Synthetic]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
BGC-823 (48.19 Inhibition ratio at 50 μg/ml)
MTT/MTS cell-proliferation and cytotoxicity assay
PaperWang C et al. Designed synthetic analogs of the alpha-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin alpha-v beta-3 homing domain. J Pept Sci. 2012. PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/
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