Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length522 amino acids

Chemical FormulaC2643H4217N689O730S16

DescriptionStandard

        MARGPDTARRWATLVVLAALGTAVTTTNPGIVARITQKGLDYACQQGVLTLQKELEKITIPNFSGNFKIKYLGKGQYSFFSMVIQGFNLPNSQIRPLPDKGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAGLNLGYDPASGHSTVTCSSCSSGINTVRIHISGSSLGWLIQLFRKRIESLLQKSMTRKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRATANNLDWLLKGEFFSLAHRSPPPFAPPALAFPSDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESKFRLTTKFFGILIPQVAKMFPDMQMQLFIWASLPPKLTMKPSGLDLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGAKSDRLIGELRLDKLLLELKHSDIGPFSVESLQSVINYVMPTIVLPVINKKLQKGFPLPLPAYIELFNLTLQPYQVSPQGLLRQISYFDSHLPPALDQALSTLPTLPQGMLLNRREDKTQGRHTAIK
    

Molecular Weight57837.97 Da

Isoelectric Point (pI)9.65

Net Charge (pH 7.0)19.09

Net Charge (pH 7.4) 18.35

Charge Density (pH 7.0) 0.0366

GRAVY Index0.05

Hydrophobic Moment 0.69

Boman Index0.11

Instability Index36.72

Aliphatic Index 102.93

Aromaticity 0.0881

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011203 VERIFIED: NO

Provenance & Taxonomy

OrganismBos indicus x Bos taurus [Animal]

FamilyBPI/LBP

Tax ID30522

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria