Peptide Database

Peptide Name4321(derived from the RNase H domain of HIV-1 RT (20-mes)),64(derived from the HIV-1 HXB2 Pol region of the viral genome)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H189N27O31

DescriptionStandard

        ELVNQIIEQLIKKEKVYLAW
    

Molecular Weight2457.90 Da

Isoelectric Point (pI)6.32

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.34

Charge Density (pH 7.0) -0.0081

GRAVY Index0.01

Hydrophobic Moment 0.68

Boman Index0.10

Instability Index25.07

Aliphatic Index 151.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 971.47

LogP -2.72

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 86.0

Heavy Atoms 174.0

Ring Count 3.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0395585 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Replication inhibition

Targetinhibition of strand transfer catalyzed by C130S integrase

Activity7±1 μM

MethodIC50

Half-LifeMammalian: 1 h; Yeast: 30 min; E. coli: >10 h

PaperInhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. | Zawahir Z, Neamati N. | Bioorg Med Chem Lett. 2006 Oct 1;16(19):5199-202. | DOI:10.1016/j.bmcl.2006.07.022 | PMID:16879966 PMID16879966 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16879966/

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