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MYP_137182
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Basic Information
Omega-conotoxin MVIIA, Ziconotide
Annotation / Sequence feature ▸ Nuclear export signal
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Ion channel inhibition
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuropeptide activity ▸ Calcium-channel blocker neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
25 amino acids
C102H177N35O33S7
Standard
Sequence
CKGKGAKCSRLMYDCCTGSCRSGKC
Physicochemical Analysis
2646.17 Da
9.13
4.70
4.40
0.1879
-0.46
0.49
-0.25
59.53
19.60
0.0400
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1128.05
-17.22
48.0
45.0
92.0
177.0
1.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0270727 VERIFIED: YES
Provenance & Taxonomy
Conus magus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus
500 μM
MIC
PMID28245769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28245769/
RECORD: Rec_0298711 VERIFIED: NO
Provenance & Taxonomy
Conus magus [Animal]
Conotoxin
Structure & Mods
linear disulfide-stabilized peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
1-16, 8-20, 15-25
Bio-Activity Profile
Toxin
RECORD: Rec_0304727 VERIFIED: YES
Provenance & Taxonomy
Conus magus [Animal]; synthetic construct [Synthetic]
ω-Conotoxin
6492;32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-16, 8-20, 15-25
Bio-Activity Profile
Analgesic Calcium-channel blocker neuropeptide
N-type voltage-gated calcium channel
Clinical/Human: 4.6 h
Evidence URLhttps://www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-060_Prialt.cfm
RECORD: Rec_0358199 VERIFIED: YES
Provenance & Taxonomy
Conus magus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida tropicalis
39.8 μM
MIC
PMID28245769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28245769/
RECORD: Rec_0374955 VERIFIED: YES
Provenance & Taxonomy
Conus magus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida kefyr
28.8 μM
MIC
PMID28245769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28245769/
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