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MYP_137182
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Basic Information
Omega-conotoxin MVIIA, Ziconotide
Annotation / Sequence feature ▸ Nuclear export signal
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Ion channel inhibition
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Neuropeptide activity ▸ Calcium-channel blocker neuropeptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Venom / Toxin ▸ Toxin
Standard
25 amino acids
C102H177N35O33S7
Standard
Sequence
CKGKGAKCSRLMYDCCTGSCRSGKC
Physicochemical Analysis
2646.17 Da
9.13
4.70
4.40
0.1879
-0.46
0.49
-0.25
59.53
19.60
0.0400
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1128.05
-17.22
48.0
45.0
92.0
177.0
1.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0125827 VERIFIED: YES
Provenance & Taxonomy
Conus magus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Human erythrocytes
4230 μM
Hemolysis
PMID28245769 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28245769/
RECORD: Rec_0125976 VERIFIED: NO
Provenance & Taxonomy
Conus magus [Animal]
Conotoxin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Amidation
1-16; 8-20; 15-25
Bio-Activity Profile
Toxin
RECORD: Rec_0171112 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 16.0%, T 44.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Miscellaneous
PaperConoServer: updated content, knowledge, and discovery tools in the conopeptide database PMID22058133 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/
RECORD: Rec_0197343 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Cytotoxic
PaperIn silico approach for predicting toxicity of peptides and proteins PMID24058508 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24058508/
RECORD: Rec_0233651 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 16.0%, T 44.0%, C 40.0% [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Miscellaneous
PaperConoServer: updated content, knowledge, and discovery tools in the conopeptide database PMID22058133 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22058133/
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