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MYP_137179
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Basic Information
NRC-03
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C132H232N48O29
Standard
Sequence
GRRKRKWLRRIGKGVKIIGGAALDHL
Physicochemical Analysis
2955.56 Da
12.00
7.84
7.58
0.3017
-0.58
0.96
-0.27
68.95
108.85
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1286.17
-10.36
49.0
38.0
106.0
209.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0157508 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
r=D-Arg; k=D-Lys
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes
>256 μg/mL
erythrocyte hemolysis assay
Paperhttps://pubmed.ncbi.nlm.nih.gov/21729875/ PMID21729875 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21729875/
RECORD: Rec_0160248 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli CGSC 4908
2 μg/mL
MIC
PaperPatrzykat A et al. Novel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003;47:2464-2470. doi:10.1128/AAC.47.8.2464-2470.2003. PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0162900 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]; synthetic construct [Synthetic]
Pleurocidin
8355
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial
MDA-MB-468
5 μM
cell-viability/cytolysis concentration-response assay
PaperHilchie AL et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102. PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
RECORD: Rec_0170826 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]; synthetic construct [Synthetic]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
4T1
5 μM
cell-viability/cytolysis concentration-response assay
PaperHilchie AL et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102. PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
RECORD: Rec_0172631 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
8265
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Antimicrobial
breast carcinoma cells
cell-viability/cytolysis concentration-response assay; in vivo xenograft growth assay
PaperHilchie AL et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102. PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
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