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MYP_137179
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Basic Information
NRC-03
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
26 amino acids
C132H232N48O29
Standard
Sequence
GRRKRKWLRRIGKGVKIIGGAALDHL
Physicochemical Analysis
2955.56 Da
12.00
7.84
7.58
0.3017
-0.58
0.96
-0.27
68.95
108.85
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1286.17
-10.36
49.0
38.0
106.0
209.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0260995 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli TOP10 peptide-expressing strain
3.75 OD_ID (dimensionless)
MeX pooled intracellular peptide-expression growth-inhibition assay (NGS-derived OD_ID at 4.5 h)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (MeX). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7. PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0263620 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]; synthetic construct [Synthetic]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial
T-47D
25 μM
cell-viability/cytolysis concentration-response assay
PaperHilchie AL et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102. PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
RECORD: Rec_0269149 VERIFIED: YES
Provenance & Taxonomy
Pleuronectes americanus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
A. salmonicida 99-1
2 μM
MIC
PaperPatrzykat A et al. Novel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003;47:2464-2470. doi:10.1128/AAC.47.8.2464-2470.2003. PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0275949 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
MRSA C623
8 μg/mL
MIC
PaperPatrzykat A et al. Novel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003;47:2464-2470. doi:10.1128/AAC.47.8.2464-2470.2003. PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0280570 VERIFIED: YES
Provenance & Taxonomy
Pseudopleuronectes americanus [Animal]; synthetic construct [Synthetic]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
4T1
10 μM
cell-viability/cytolysis concentration-response assay
PaperHilchie AL et al. Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 2011;13:R102. PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
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