Peptide Database

Peptide NamespoIIR signal peptide

Function Ontology

Annotation / Sequence feature ▸ Signal peptide

Biotechnology / Production and expression ▸ Secretory enzyme production ▸ Cutinase secretion

Biotechnology / Production and expression ▸ Secretory expression optimization

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H184N22O24S2

DescriptionStandard

        MKKTVIICIYIFLLLSGALV
    

Molecular Weight2238.88 Da

Isoelectric Point (pI)9.19

Net Charge (pH 7.0)1.49

Net Charge (pH 7.4) 1.25

Charge Density (pH 7.0) 0.0744

GRAVY Index1.98

Hydrophobic Moment 0.24

Boman Index0.61

Instability Index5.25

Aliphatic Index 190.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 728.95

LogP 0.45

H-bond Donors 27.0

H-bond Acceptors 28.0

Rotatable Bonds 75.0

Heavy Atoms 156.0

Ring Count 2.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0229922 VERIFIED: YES

Provenance & Taxonomy

OrganismBacillus subtilis [Bacterium]

FamilySec signal peptide

Tax ID1423

Structure & Mods

Configlinear signal peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Protein secretion signal peptide Secretory expression optimization Cutinase secretion

TargetBacillus subtilis TEB1030

MethodSecretion phenotype assay

PaperBrockmeier U, Caspers M, Freudl R, et al. Systematic screening of all signal peptides from Bacillus subtilis: A powerful strategy in optimizing heterologous protein secretion in gram-positive bacteria[J]. Journal of Molecular Biology, 2006, 362(3): 393-402. PMID16930615 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16930615/