Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length495 amino acids

Chemical FormulaC2434H3903N653O686S24

DescriptionStandard

        MARGPDNTLQWATLVVLAAVGTAVTAATNPGVVARITQKGLDYACQQGVAVLQKELEKMKIPDMSGSVKMKPFGKGHYNFYSMDVRGFQLPSSQMKLLPDEGLGLSIRNANVKIGGKWKARKSFIKTSGNFELNVEGVSISAGLRLGQEPASRRLTASCSSCSSNIDGVRLHVSGSSLGWLIKLFHKKIESSLRKAMNNKICEIMTHSVSSKLQPYLQTLPVTTKIDKVAWIDYSLVAPLRVTAENLDGQMKGEFFNPAHRDPPPFAPPALAFPADHDRMVYLGLSDYLFNTAGLVYHKAGVLKMTLKDSMVAKVFPNMKMQFFFGTASPPQLTMSPAGLVLTPTLEAQAFVVFPNSSLVPLFLLEMSTNISLEVSARSNRLVGKVKMDKLLLKLKHSVIGSFPVQLLQSIMNYVVPTLVLPKVNERLQEGFPLPLPSRIQVFNLVIRSYQVSPKVSVHQTSHNTGNPLLESCLRATWYGVPSALTTALEGGGCE
    

Molecular Weight54059.55 Da

Isoelectric Point (pI)9.66

Net Charge (pH 7.0)20.34

Net Charge (pH 7.4) 19.42

Charge Density (pH 7.0) 0.0411

GRAVY Index0.03

Hydrophobic Moment 0.69

Boman Index0.10

Instability Index47.47

Aliphatic Index 94.30

Aromaticity 0.0747

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44265.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0425013 VERIFIED: NO

Provenance & Taxonomy

OrganismEquus caballus [Animal]

FamilyBPI

Tax ID9796

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence