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MYP_136860
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Basic Information
LL-37(17-29) (C-terminal fragment of LL-37, LL; Human, mammals, animals)
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C80H135N25O17
Standard
Sequence
FKRIVQRIKDFLR
Physicochemical Analysis
1719.09 Da
11.72
3.76
3.55
0.2892
-0.44
0.97
-0.39
18.70
112.31
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
730.65
-3.72
27.0
21.0
61.0
122.0
2.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0271028 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral Anticancer Antiparasitic Anti-inflammatory
Also S. hominis
39 μM
MIC
PaperSolution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region.
RECORD: Rec_0273623 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
Escherichia coli UB 1005
16 μM
MIC
PaperPubMed PMID: 16637646 | PubMed PMID: 28178190 | LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. Biochim Biophys Acta Biomembr. 2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037. PMID: 28161291. | Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. ChemMedChem. 2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264. PMID: 23894079. PMID16637646;28178190;28161291;23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0317694 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0329776 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer
PaperPubMed PMID: 16637646 | PubMed PMID: 28178190 | LL-37-derived membrane-active FK-13 analogs possessing cell selectivity, anti-biofilm activity and synergy with chloramphenicol and anti-inflammatory activity. Biochim Biophys Acta Biomembr. 2017 May;1859(5):722-733. doi: 10.1016/j.bbamem.2017.01.037. PMID: 28161291. | Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. ChemMedChem. 2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264. PMID: 23894079. PMID16637646;28178190;28161291;23894079 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0331778 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
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