Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length458 amino acids

Chemical FormulaC2279H3631N575O644S17

DescriptionStandard

        MILLWCLVLVAFTSTTFGTNPGVQVRLTQKGLEYGRQLGIVSLQQKLGSITIPDFSGSQSVSPIGKVKYSLTNIKLVNVGLPKSALDLVPGTGVRLSIGDAFMSLHGDWRVKYLRWIKDSGSFDVSVNGLSITTSIVVISDETGRPAVSVAKCAASVTSAKVKFHGGASWLYNLFSKFIDKALRNALQKQICPLVVKAVADLNPKLKTLNVLAKVDKYAEIEYSMVSSPVVAKSTLDLSLKGEFYNIEKHQEPPFSPAAFSLPPQTDNMVYIALSAFTPNSAGFVYNKAGVMSLYITDDMVPKESPVRLNTKMFGVFIPQIKKQFPNLMMKLLLKTVDNPTITFQPKNATVEVNATMTAYAIQPNGTLSPLFVLNMESSVSTNVFVSGLNIAGKVSLNRMKLTLGTSYVGQFQVSTLNSIFQTMLKVVVIPIVNGEFFYSRFSKVNVVIPGFDASNMF
    

Molecular Weight49934.78 Da

Isoelectric Point (pI)9.61

Net Charge (pH 7.0)16.73

Net Charge (pH 7.4) 16.22

Charge Density (pH 7.0) 0.0365

GRAVY Index0.23

Hydrophobic Moment 0.84

Boman Index0.17

Instability Index33.24

Aliphatic Index 100.57

Aromaticity 0.0939

Extinction Coeff. Reduced 41370.00

Extinction Coeff. Oxidized 41495.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0421836 VERIFIED: NO

Provenance & Taxonomy

OrganismIconisemion striatum [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria