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MYP_136766
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Basic Information
FP1 (Tkip)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
12 amino acids
C93H118N16O14
Standard
Sequence
WLVFFVIFYFFR
Physicochemical Analysis
1684.03 Da
8.75
0.76
0.55
0.0633
2.00
0.37
0.76
46.62
113.33
0.5833
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
481.34
5.28
18.0
15.0
47.0
123.0
8.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0026217 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Influenza A virus (Virus entry); MDCK
0.0936 μM
Plaque assay
PaperA novel family of peptides with potent activity against influenza A viruses. | Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA. | J Gen Virol. 2012 | PMID:22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0043824 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
influenza A virus A/WSN/33 H1N1:inhibition of viral replication in MDCK cells
0.0936 μM
IC50
PaperPubMed PMID: 22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0175284 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0315509 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Fusion inhibition
Influenza A virus A/WSN/33 H1N1 | MDCK cells
0.0936 μM
IC50
Mammalian: 2.8 h; Yeast: 3 min; E. coli: 2 min
PaperA novel family of peptides with potent activity against influenza A viruses. | Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA. | J Gen Virol. 2012 May;93(Pt 5):980-986. | DOI:10.1099/vir.0.038679-0 | PMID:22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0359259 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 25.0%, C 75.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/