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MYP_136721
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Basic Information
SAU-7
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C71H113N15O19
Standard
Sequence
GLFDIIKKIAESF
Physicochemical Analysis
1480.75 Da
6.07
-0.24
-0.45
-0.0183
0.67
0.71
0.30
20.48
127.69
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
559.39
-1.87
19.0
19.0
51.0
105.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0334229 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 76.9%, E 0.0%, T 0.0%, C 23.1% [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Antiviral Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0340898 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida glabrata ATCC 1182
>128 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0345457 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 3 and 7) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (3) and Ⓧ (7) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida auris 919
>128 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0349785 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0352120 VERIFIED: YES
Provenance & Taxonomy
Southern bell [Animal]
Aurein
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
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