‹ ›
MYP_136721
← PREVIOUS NEXT → BACK
Basic Information
SAU-7
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C71H113N15O19
Standard
Sequence
GLFDIIKKIAESF
Physicochemical Analysis
1480.75 Da
6.07
-0.24
-0.45
-0.0183
0.67
0.71
0.30
20.48
127.69
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
559.39
-1.87
19.0
19.0
51.0
105.0
2.0
12.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0276593 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 8 and 12) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (8) and Ⓧ (12) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida parapsilosis ATCC 22010
>128 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0277796 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 3 and 7) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (3) and Ⓧ (7) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida glabrata 896
>128 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0277944 VERIFIED: YES
Provenance & Taxonomy
Litoria raniformis [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Breast tumor cell line
10 μM
LC50
PaperThe antibiotic and anticancer active aurein peptides from the Australian Bell Frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2 PMID10951191 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10951191/
RECORD: Rec_0282344 VERIFIED: YES
Provenance & Taxonomy
Ranoidea raniformis [Animal]
116057
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pasteurella multocida
100 μg/mL
MIC
PaperThe antibiotic and anticancer active aurein peptides from the australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2.
RECORD: Rec_0288051 VERIFIED: YES
Provenance & Taxonomy
Litoria auream [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
C. auris 919
128 μg/mL
MIC
PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
FIRST PREV 1 ... 23 24 25 26 27 ... 37 NEXT LAST
Showing 5 records on this page · Page 25 of 37