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MYP_136721
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Basic Information
SAU-7
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antiviral
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C71H113N15O19
Standard
Sequence
GLFDIIKKIAESF
Physicochemical Analysis
1480.75 Da
6.07
-0.24
-0.45
-0.0183
0.67
0.71
0.30
20.48
127.69
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
559.39
-1.87
19.0
19.0
51.0
105.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014289 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 2 and 6) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (2) and Ⓧ (6) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida glabrata 896
128 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.2 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0018022 VERIFIED: YES
Provenance & Taxonomy
Litoria auream [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans SC5314
64 μg/mL
MIC
PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0021844 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
The Ⓧ (position: 9 and 13) in sequence indicates S5 (2-amino-2-methylhept-6-enoic acid). Ⓧ (9) and Ⓧ (13) are cross-linked by hydrocarbon stapling respectively
Bio-Activity Profile
Antifungal
Candida albicans SC5314
>64 μg/mL
MIC
PaperZheng M, Wang R, Chen S, Zou Y, Yan L, Zhao L, Li X. Design, Synthesis and Antifungal Activity of Stapled Aurein1.4 Peptides. Antibiotics (Basel). 2021 Aug 9;10(8):956. PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
RECORD: Rec_0029489 VERIFIED: YES
Provenance & Taxonomy
Litoria aurea [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Cryptococcus neoformans
1000 μg/mL
MIC
PMID31264322 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31264322/
RECORD: Rec_0030433 VERIFIED: YES
Provenance & Taxonomy
Litoria auream [Animal]
Aurein
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antifungal
Candida glabrata ATCC1182
128 μg/mL
MIC
PMID34439006 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34439006/
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