Peptide Database

Peptide NameCholecystokinin-33

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC168H264N50O50S3

DescriptionStandard

        KAPSGRMSIIKNLQNLDPSHRISDRDYMGWMDF
    

Molecular Weight3880.39 Da

Isoelectric Point (pI)8.50

Net Charge (pH 7.0)0.85

Net Charge (pH 7.4) 0.59

Charge Density (pH 7.0) 0.0257

GRAVY Index-0.82

Hydrophobic Moment 0.53

Boman Index-0.17

Instability Index67.49

Aliphatic Index 62.12

Aromaticity 0.0909

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1638.77

LogP -16.49

H-bond Donors 57.0

H-bond Acceptors 55.0

Rotatable Bonds 129.0

Heavy Atoms 271.0

Ring Count 7.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0076661 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyGastrin/cholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr27 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0101846 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods27:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min

RECORD: Rec_0145022 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0294779 VERIFIED: YES

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyCholecystokinin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods27:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 1.3 hour; Yeast: 3 min; E. coli: 2 min