‹ ›
MYP_136401
← PREVIOUS NEXT → BACK
Basic Information
DET2
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
10 amino acids
C55H84N12O15
Standard
Sequence
PWLKPGDLDL
Physicochemical Analysis
1153.33 Da
4.21
-1.04
-1.10
-0.1040
-0.40
0.25
0.14
2.43
117.00
0.1000
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
418.85
-0.74
14.0
14.0
34.0
82.0
4.0
9.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0102129 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); LLC-MK2
40.6 %
Plaque assay
PaperInhibition of dengue virus entry into target cells using synthetic antiviral peptides. | Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD. | Int J Med Sci. 2013 | PMID:23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0147613 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue virus 2(DENV2) | LLC-MK2 cells
500 μM
IC50
Mammalian: >20 h; Yeast: >20 h; E. coli: ?
PaperInhibition of dengue virus entry into target cells using synthetic antiviral peptides. | Alhoot MA, Rathinam AK, Wang SM, Manikam R, Sekaran SD. | Int J Med Sci. 2013 Apr 16;10(6):719-29. | DOI:10.7150/ijms.5037 | PMID:23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0159615 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
dengue virus 2(DENV2):inhibition of viral replication in LLC-MK2 cells
>500 μM
IC50
PaperPubMed PMID: 23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
RECORD: Rec_0168126 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0171984 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 23630436 PMID23630436 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23630436/
1 2 NEXT LAST
Showing 5 records on this page · Page 1 of 2