Peptide Database

Peptide NameSLAY-screened peptide P1740

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H161N27O27

DescriptionStandard

        PLRGLAGTPLIHLYTIHSSY
    

Molecular Weight2209.54 Da

Isoelectric Point (pI)9.01

Net Charge (pH 7.0)1.13

Net Charge (pH 7.4) 0.97

Charge Density (pH 7.0) 0.0565

GRAVY Index0.28

Hydrophobic Moment 0.19

Boman Index0.28

Instability Index28.36

Aliphatic Index 122.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 834.08

LogP -6.06

H-bond Donors 31.0

H-bond Acceptors 30.0

Rotatable Bonds 66.0

Heavy Atoms 157.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021358 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/