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MYP_136367
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Basic Information
Anxiolytic peptide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-IV inhibition ▸ DPP-IV inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Metabolic ▸ Glucose metabolism ▸ Antidiabetic
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Standard
2 amino acids
C15H22N2O4
Standard
Sequence
YL
Physicochemical Analysis
294.35 Da
5.52
-0.24
-0.45
-0.1205
1.25
0.52
0.66
5.00
195.00
0.5000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
112.65
0.88
4.0
4.0
7.0
21.0
1.0
1.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014032 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
PaperKanegawa N., Suzuki C., Ohinata K.. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett., 584, 599-604, 2010.
RECORD: Rec_0029472 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
ACE-inhibitory peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
122 μM
IC50
PaperSynthetic peptides corresponding to alpha-lactalbumin and beta-lactoglobulin sequences with angiotensin-I-converting enzyme inhibitory activity. PMID8737991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8737991/
RECORD: Rec_0036274 VERIFIED: YES
Provenance & Taxonomy
Sardinops melanosticus [Animal] [Plant]; Amaranthus hypochondriacus [Plant]
Angiotensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory Neuropeptide Antimicrobial Antibacterial DPP-IV Inhibitory
Dipeptidyl peptidase IV
940.2 μM
IC50
RECORD: Rec_0038565 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]; Viridiplantae [Plant]; Actinopterygii [Animal]; Poaceae [Plant]; Sus scrofa [Animal]; Insecta [Animal]
9913; 33090; 7898; 4479; 9823; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
PaperStructural requirements of Angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship study of di- and tripeptides PMID16448176 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16448176/
RECORD: Rec_0067095 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. [Bacterium]
Structure & Mods
cyclic peptide topology [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antifungal
Rhizoctonia solani MTCC 4634
32 μg/mL
MIC
PMID23672207 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23672207/
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