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MYP_136366
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Basic Information
Leaf cyclotide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ CPE inhibition
not Standard
31 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
CGESCAXISFCFTEVIGCSCKNKVCYLNSIS
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0374698 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
180952
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
not reported
not reported
1-18, 5-20, 11-25
The 'X' at position 7 indicates Methionine sulfoxide. The N-terminal and C-terminal cyclized by a amide bond. Disulfide bonds between Cys1 and Cys18, Cys5 and Cys20, Cys11 and Cys25.
Bio-Activity Profile
Antiviral Anti-HIV-1 CPE inhibition
HIV-1
0.87 μM
EC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperIsolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide. | Chen B, Colgrave ML, Daly NL, Rosengren KJ, Gustafson KR, Craik DJ. | J Biol Chem. 2005 Jun 10;280(23):22395-405. | DOI:10.1074/jbc.M501737200 | PMID:15824119 PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0411162 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
1-18, 5-20, 11-25
The 'X' at position 7 indicates Methionine sulfoxide. The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of cytopathic effect
0.87 μM
EC50
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
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