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MYP_136366
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Basic Information
Leaf cyclotide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Enzyme modulation ▸ Enzyme inhibition ▸ CPE inhibition
not Standard
31 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
CGESCAXISFCFTEVIGCSCKNKVCYLNSIS
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0074520 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 7 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-HIV
HIV
0.87 μM
EC50
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0119336 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 7 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-negative
Escherichia coli
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0135566 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
No specific N-terminal
No specific C-terminal
1-18, 5-20, 11-25
The 'X' at position 7 indicates Methionine sulfoxide. The N-terminal and C-terminal cyclized by a amide bond
Bio-Activity Profile
Antimicrobial Antiviral
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0153885 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 7 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral
Candida albicans
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0320392 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 7 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Antiviral Anti-Gram-positive
Staphylococcus aureus
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
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