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MYP_136337
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Basic Information
HIV-1 Tat (48-60)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
14 amino acids
C73H136N36O17S
Standard
Sequence
GRKKRRQRRRPPQC
Physicochemical Analysis
1822.16 Da
12.00
7.75
7.53
0.5534
-3.06
0.48
-1.35
204.96
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
933.66
-12.36
36.0
26.0
64.0
127.0
2.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0328760 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
Synthetic CPP
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide
9 L/LacZ cells
Cellular uptake assay
Evidence URLhttps://patents.google.com/patent/US20060035815 PatentUS20060035815
RECORD: Rec_0340452 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Tat
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Cell-penetrating peptide Cargo delivery
PMID12119035 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12119035/
RECORD: Rec_0368488 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Labelled rhodamine
Amidation
Bio-Activity Profile
Drug Delivery Vehicle Cell-penetrating peptide
PaperCPPsite: a curated database of cell penetrating peptides PMID22403286 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22403286/
RECORD: Rec_0426497 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
Tat
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Fluorophore labeling
C-term detail: Alexa 488 labeling at glycyl cysteine sequence
Bio-Activity Profile
Cell-penetrating peptide
CHO-K1; HeLa; Jurkat
Fluorescence-based uptake assay
PMID19707187 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19707187/
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