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MYP_136251
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Basic Information
IB-367
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Standard
17 amino acids
C78H129N29O19S4
Standard
Sequence
RGGLCYCRGRFCVCVGR
Physicochemical Analysis
1905.30 Da
9.37
3.72
3.46
0.2188
0.24
0.30
-0.14
-7.18
57.06
0.1176
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
796.75
-9.00
35.0
27.0
61.0
130.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0183006 VERIFIED: YES
Provenance & Taxonomy
synthetic construct based on Clinical trials [Synthetic]
Protegrin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus 209P or ATCC 29213 or MRSA
2-4 μM
MIC
PaperDesign of Protegrin-1 Analogs with Improved Antibacterial Selectivity. PMID37631261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37631261/
RECORD: Rec_0188619 VERIFIED: YES
Provenance & Taxonomy
synthetic construct based on Clinical trials [Synthetic]
Protegrin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa PAO1 or ATCC 27853 or ATCC 9027
2-8 μM
MIC
PaperDesign of Protegrin-1 Analogs with Improved Antibacterial Selectivity. PMID37631261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37631261/
RECORD: Rec_0191646 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-14, 7-12
Bio-Activity Profile
Antibacterial Antifungal Anti-inflammatory Anti-mucositis
Staphylococcus spp. (35)
0.13-4 μg/mL
MIC
PaperA phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leukoc. Res.(2004) PMID15120931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15120931/
RECORD: Rec_0194290 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-14, 7-12
Bio-Activity Profile
Antibacterial Antifungal Anti-inflammatory Anti-mucositis
Klebsiella pneumoniae (4)
1-5 μg/mL
MIC
PaperA phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leukoc. Res.(2004) PMID15120931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15120931/
RECORD: Rec_0206555 VERIFIED: YES
Provenance & Taxonomy
synthetic construct based on Clinical trials [Synthetic]
Protegrin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Corynebacterium spp
0.13-0.25 μg/mL
MIC
PaperDesign of Protegrin-1 Analogs with Improved Antibacterial Selectivity. PMID37631261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37631261/
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