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MYP_136251
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Basic Information
IB-367
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Standard
17 amino acids
C78H129N29O19S4
Standard
Sequence
RGGLCYCRGRFCVCVGR
Physicochemical Analysis
1905.30 Da
9.37
3.72
3.46
0.2188
0.24
0.30
-0.14
-7.18
57.06
0.1176
1490.00
1740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
796.75
-9.00
35.0
27.0
61.0
130.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0037005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
5
Bio-Activity Profile
Antimicrobial Antibacterial
methicillin-resistant Staphylococcus aureus
0.5 μg/mL
MIC
PMID10931444 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10931444/
RECORD: Rec_0037277 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-14, 7-12
Bio-Activity Profile
Antibacterial Antifungal Anti-inflammatory Anti-mucositis
Streptococcus spp. (16)
1.3-16 μg/mL
MIC
PaperA phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leukoc. Res.(2004) PMID15120931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15120931/
RECORD: Rec_0042890 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-14, 7-12
Bio-Activity Profile
Antibacterial Antifungal Anti-inflammatory Anti-mucositis
S. mitis (15)
2-43 μg/mL
MIC
PaperA phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leukoc. Res.(2004) PMID15120931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15120931/
RECORD: Rec_0047585 VERIFIED: YES
Provenance & Taxonomy
Sus scrofa [Animal]
Protegrin
9823
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-14, 7-12
Bio-Activity Profile
Antibacterial Antifungal Anti-inflammatory Anti-mucositis
S. mutans (3)
0.7-1.3 μg/mL
MIC
PaperA phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy. Leukoc. Res.(2004) PMID15120931 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15120931/
RECORD: Rec_0058570 VERIFIED: YES
Provenance & Taxonomy
synthetic construct based on Clinical trials [Synthetic]
Protegrin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae 4 strains
1-5 μg/mL
MIC
PaperDesign of Protegrin-1 Analogs with Improved Antibacterial Selectivity. PMID37631261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/37631261/
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