Peptide Database

Peptide NameMTSC22EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length24 amino acids

Chemical FormulaC141H222N32O43S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIKKS
    

Molecular Weight3085.53 Da

Isoelectric Point (pI)5.19

Net Charge (pH 7.0)-1.49

Net Charge (pH 7.4) -1.73

Charge Density (pH 7.0) -0.0620

GRAVY Index-1.42

Hydrophobic Moment 0.69

Boman Index-0.29

Instability Index55.54

Aliphatic Index 65.00

Aromaticity 0.1250

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1262.34

LogP -5.93

H-bond Donors 44.0

H-bond Acceptors 43.0

Rotatable Bonds 111.0

Heavy Atoms 217.0

Ring Count 5.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417880 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antiviral

TargetHIV-1 NL4-3:inhibition of pseudovirus entry in TZM-bl cells

Activity0.0024±0.0003 μM

MethodIC50

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. Viruses. 2019 Jul 3;11(7):609. doi: 10.3390/v11070609. PMID: 31277353. PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

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