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MYP_136213
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Basic Information
MTSC22EK
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
24 amino acids
C141H222N32O43S
Standard
Sequence
MTWEEWDKKIEEYTKKIEELIKKS
Physicochemical Analysis
3085.53 Da
5.19
-1.49
-1.73
-0.0620
-1.42
0.69
-0.29
55.54
65.00
0.1250
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1262.34
-5.93
44.0
43.0
111.0
217.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135229 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 HXB2 | TZM-bl cells
0.0022±0.0009 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/
RECORD: Rec_0240792 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Acute myeloid leukemia AML-M7
PMID31805154;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31805154/
RECORD: Rec_0297737 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 NL4-3 D36G
PMID31805154;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31805154/
RECORD: Rec_0319930 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 PsV
PMID31805154;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31805154/
RECORD: Rec_0332320 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV-1 JRCSF
PMID31805154;31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31805154/
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