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MYP_136207
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Basic Information
LL-37(17-32)(C-terminal fragment of LL-37; Human, mammals, animals)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C95H161N29O21
Standard
Sequence
FKRIVQRIKDFLRNLV
Physicochemical Analysis
2045.48 Da
11.72
3.76
3.55
0.2349
-0.07
0.97
-0.23
24.78
133.75
0.1250
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
861.04
-4.68
31.0
25.0
72.0
145.0
2.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0001571 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Anticancer
Drug-sensitive KB cancer cells
30 μM
LC50
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0003258 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Anticancer
Escherichia coli K12
20 μM
MIC
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0032019 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LL-37/Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial
KBv
30 μM
LC50
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
RECORD: Rec_0077195 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0106127 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
LL-37/Cathelicidin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Cytotoxic
KB
30 μM
LC50
PMID16637646 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16637646/
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