Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2266H3643N591O654S20

DescriptionStandard

        MFLCCWLVLGALFPATLSINPGVKVRLTEKGIEYGRQLGMADMQQKLNSIQVPDFSGKQRVSPIGKVQYNLSNIRVLKVGIPKSSVDLVPGTGVRMSIGDAFISLNGNWRVKYLRIIKHSGSFELNVNGLSIATTISIKTDETGRPAVSSDSCSAAVGSAKVKFHGGASWLYNLFTRFIDKALRNAIQKQICPRATTVVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFNLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSPIRLNTITFGVIIPEIAKQFPGLMMKLLVKMEKTPTLTFEPNNATVQATTTVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSNVGDFQVRSAFLYNNIQLAKGYPLPTIGKMKLMNTQLDVLKDYILIGTDVQFS
    

Molecular Weight50271.03 Da

Isoelectric Point (pI)9.52

Net Charge (pH 7.0)14.73

Net Charge (pH 7.4) 14.21

Charge Density (pH 7.0) 0.0320

GRAVY Index0.11

Hydrophobic Moment 0.93

Boman Index0.13

Instability Index33.38

Aliphatic Index 99.17

Aromaticity 0.0804

Extinction Coeff. Reduced 34380.00

Extinction Coeff. Oxidized 34630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0050480 VERIFIED: NO

Provenance & Taxonomy

OrganismAstatotilapia calliptera [Bacterium]

FamilyBPI

Tax ID8154

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence