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MYP_136181
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Basic Information
Unnamed
Enzyme modulation ▸ Enzyme inhibition ▸ DPP-III Inhibitory
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
5 amino acids
C29H39N5O7
Standard
Sequence
YAGFL
Physicochemical Analysis
569.65 Da
5.52
-0.24
-0.45
-0.0482
1.34
0.22
0.72
55.36
98.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.95
0.23
7.0
7.0
15.0
41.0
2.0
4.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0052671 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0175717 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Endomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
DPP-III Inhibitory
Dipeptidyl peptidase III
PaperBarsun M., Jajcanin N., Vukelic B., Spoljaric J., Abramic M.. Human dipeptidyl peptidase III acts as a post-prolinecleaving enzyme on endomorphins. Biological Chemistry, 388, 343-348, 2007.
RECORD: Rec_0185030 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Opioid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID10406217 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10406217/
RECORD: Rec_0217319 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pentapeptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-melanogenic Antioxidant
Human melanoma cell line (MNT-1) (In vitro)
Cell viability assay; Cytotoxicity assay; Immunostaining; qRT-PCR; Tyrosinase assay; Histology
PaperD-tyrosine adds an anti-melanogenic effect to cosmetic peptides PMID31937863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31937863/
RECORD: Rec_0235489 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Pentapeptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anti-melanogenic Antioxidant
RAW 264.7 (In vitro)
Cell viability assay; Cytotoxicity assay; Immunostaining; qRT-PCR; Tyrosinase assay; Histology
PaperD-tyrosine adds an anti-melanogenic effect to cosmetic peptides PMID31937863 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31937863/
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