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MYP_136148
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Basic Information
Desotamide F
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLXXNG
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213405 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. MST-115088 [Bacterium]
Structure & Mods
backbone-cyclized hexapeptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
X3=D-allo-isoleucine; X4=allo-isoleucine; backbone cyclization
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human colon adenocarcinoma SW620
>30 µM
Cytotoxicity IC50
PaperWollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0216304 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. MST-115088 [Bacterium]
Structure & Mods
backbone-cyclized hexapeptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
X3=D-allo-isoleucine; X4=allo-isoleucine; backbone cyclization
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus subtilis ATCC 6051
3.7 μM
MIC
PaperWollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0220049 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. MST-115088 [Bacterium]
Structure & Mods
backbone-cyclized hexapeptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X3=D-allo-isoleucine; X4=allo-isoleucine; backbone cyclization
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
NCI-H460 human lung carcinoma cells; SW620 human colon adenocarcinoma cells; HepG2 human hepatocellular carcinoma cells
>30 µM
Cytotoxicity IC50
PaperWollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0274385 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. MST-115088 [Bacterium]
Structure & Mods
backbone-cyclized hexapeptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
I3: D-allo-Isoleucine; I4: allo-Isoleucine
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus; Bacillus subtilis
Qualitative antibacterial activity assay
RECORD: Rec_0294578 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. MST-115088 [Bacterium]
Structure & Mods
backbone-cyclized hexapeptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X3=D-allo-isoleucine; X4=allo-isoleucine; backbone cyclization
Bio-Activity Profile
Antimicrobial Anticancer
NCI-H460 human lung carcinoma cells; SW620 human colon adenocarcinoma cells; HepG2 human hepatocellular carcinoma cells
>30 µM
Cytotoxicity IC50
PaperWollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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