Peptide Database

Peptide NamesHR2-1

Function Ontology

Antiviral

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC311H500N82O108

DescriptionStandard

        LDSPKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYE
    

Molecular Weight7115.78 Da

Isoelectric Point (pI)4.47

Net Charge (pH 7.0)-7.13

Net Charge (pH 7.4) -7.41

Charge Density (pH 7.0) -0.1131

GRAVY Index-0.69

Hydrophobic Moment 0.70

Boman Index-0.10

Instability Index39.74

Aliphatic Index 102.06

Aromaticity 0.0476

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3125.40

LogP -31.73

H-bond Donors 102.0

H-bond Acceptors 102.0

Rotatable Bonds 248.0

Heavy Atoms 501.0

Ring Count 6.0

Amide Bonds 70.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0238883 VERIFIED: YES

Provenance & Taxonomy

OrganismSevere acute respiratory syndrome-related coronavirus [Virus]

FamilyVirus-derived peptide

Tax ID694009;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetSARS coronavirus (Fusion); Vero

Activity43 μM

MethodEC50

PaperSevere acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides. | Bosch BJ, Martina BE, Van Der Zee R, Lepault J, Haijema BJ, Versluis C, Heck AJ, De Groot R, Osterhaus AD, Rottier PJ. | Proc Natl Acad Sci U S A. 2004 | PMID:15150417 PMID15150417 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15150417/