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MYP_136027
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Basic Information
Palustrin-1b
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
28 amino acids
C143H239N39O34S3
Standard
Sequence
ALFSILRGLKKLGNMGQAFVNCKIYKKC
Physicochemical Analysis
3144.86 Da
10.05
5.77
5.54
0.2061
0.24
0.81
0.07
7.21
101.07
0.1071
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1210.75
-8.68
44.0
43.0
111.0
219.0
3.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0032947 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
298395
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
22-28
Bio-Activity Profile
Antimicrobial
Candida albicans
>150 μM
MIC
PaperMultiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0055935 VERIFIED: YES
Provenance & Taxonomy
Rana palustris [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
22-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
8 μM
MIC
PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0213475 VERIFIED: YES
Provenance & Taxonomy
Lithobates palustris [Animal]
Palustrin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
22-28
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
8.0 μM
MIC
PaperY.J. Basir et al. / Biochimica et Biophysica Acta 1543 (2000) 95-105. Multiple antimicrobial peptides and peptides related to bradykinin and neuromedin N isolated from skin secretions of the pickerel frog, Rana palustris PMID11087945 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11087945/
RECORD: Rec_0243509 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0305877 VERIFIED: NO
Provenance & Taxonomy
American frog [Animal]
Palustrin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
22-28
Bio-Activity Profile
Antimicrobial
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