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MYP_136020
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Basic Information
Ep-AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
35 amino acids
C148H244N48O45S6
Standard
Sequence
CVLIGQRCDNDRGPRCCSGQGNCVPLPFLGGVCAV
Physicochemical Analysis
3608.20 Da
7.78
0.70
0.41
0.0201
0.28
0.47
0.08
20.96
80.57
0.0286
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1479.24
-19.15
55.0
52.0
113.0
247.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0182068 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213
0.63 μM
Minimum concentration for >99% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0185277 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial
Solution NMR structure determination
PaperPDB 2MFS structural record; NMR; chain A; residues 1-35 PMID25821084
RECORD: Rec_0210074 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
2.5 μM
Minimum concentration for >99% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0212125 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
>160 μM
Minimum concentration for 100% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0236670 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
None
None
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Qualitative antimicrobial/cytotoxicity evidence
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
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