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MYP_136020
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Basic Information
Ep-AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
35 amino acids
C148H244N48O45S6
Standard
Sequence
CVLIGQRCDNDRGPRCCSGQGNCVPLPFLGGVCAV
Physicochemical Analysis
3608.20 Da
7.78
0.70
0.41
0.0201
0.28
0.47
0.08
20.96
80.57
0.0286
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1479.24
-19.15
55.0
52.0
113.0
247.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0099444 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
None
None
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
Qualitative antimicrobial/cytotoxicity evidence
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0105340 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Cyclotide
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
1.25 μM
Minimum concentration for 100% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0107252 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
10 μM
Minimum concentration for >99% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0135667 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Cyclotide
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-negative
Pseudomonas aeruginosa
Qualitative antimicrobial/cytotoxicity evidence
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0143967 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Cyclotide
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
Qualitative antimicrobial/cytotoxicity evidence
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
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