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MYP_136020
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Basic Information
Ep-AMP1
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
35 amino acids
C148H244N48O45S6
Standard
Sequence
CVLIGQRCDNDRGPRCCSGQGNCVPLPFLGGVCAV
Physicochemical Analysis
3608.20 Da
7.78
0.70
0.41
0.0201
0.28
0.47
0.08
20.96
80.57
0.0286
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1479.24
-19.15
55.0
52.0
113.0
247.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024397 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213[MBC50 = 0.31 microM]
PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0053646 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida albicans
PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0089088 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0097886 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028[MBC50 = 160 microM]
PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0099360 VERIFIED: YES
Provenance & Taxonomy
Plantae [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
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