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MYP_136020
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Basic Information
Ep-AMP1
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
35 amino acids
C148H244N48O45S6
Standard
Sequence
CVLIGQRCDNDRGPRCCSGQGNCVPLPFLGGVCAV
Physicochemical Analysis
3608.20 Da
7.78
0.70
0.41
0.0201
0.28
0.47
0.08
20.96
80.57
0.0286
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1479.24
-19.15
55.0
52.0
113.0
247.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024397 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213
0.31 µM
Minimum concentration for >50% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0053646 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Cyclotide
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Candida albicans
>160 µM
Minimum concentration for >99% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0089088 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antibacterial Antimicrobial
Escherichia coli TOP10
8.92 OD_ID ratio at 4.5 h (dimensionless)
Me^x pooled growth assay
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0097886 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
160 µM
Minimum concentration for >50% microbicidal effect
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
RECORD: Rec_0099360 VERIFIED: YES
Provenance & Taxonomy
Echinopsis pachanoi [Plant]
Structure & Mods
disulfide-constrained inhibitor cystine-knot peptide with linear backbone [Linear]
canonical L-amino-acid peptide [L]
None
None
1-17; 8-23; 16-33
Bio-Activity Profile
Antimicrobial Anticancer
-
Qualitative antimicrobial/cytotoxicity evidence
PaperA cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. PMID25821084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25821084/
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